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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > CL097CAS：1026249-18-2
Molecular Formula：C13H14N4O
Molecular Weight：242.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1026249-18-2 |
| Name | CL097 |
| Molecular Formula | C13H14N4O |
| Molecular Weight | 242.28 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD32633372 |
| SMILES | CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N |
| InChIKey | DEVCLHVFELRPIU-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H14N4O/c1-2-18-7-10-16-11-8-5-3-4-6-9(8)15-13(14)12(11)17-10/h3-6H，2，7H2，1H3，(H2，14，15)(H，16，17) |
| PubChem CID | 11579618 |
| Target Point | Toll-like Receptor (TLR7/8) |
| Passage | Immunology & Inflammation |
| Background | CL097 is an effective TLR7 and TLR8 agonist. |
| Biological Activity | CL097， a potent TLR7 and TLR8 agonist， induces pro-inflammatory cytokines in macrophages[1]. CL097 induces NADPH oxidase priming， resulting in an increase of the fMLF-stimulated ROS production[2]. |
| Data Literature Source | [1]. Cindy Patinote，et al. Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes. Eur J Med Chem. 2020 May 1;193:112238. [2]. Karama Makni-Maalej，et al. The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1. J Immunol. 2012 Nov 1;18 [3]. A S Lee，et al. Toll-like receptor 7 stimulation promotes autoimmune diabetes in the NOD mouse. Diabetologia. 2011 Jun;54(6):1407-16. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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