Liothyronine Sodium
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Cat.No：IL2370 Solarbio
CAS：1955/6/1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
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HIF
Immunology & Inflammation
Stem Cells
Apoptosis
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ER Stress
Cell Cycle
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > Liothyronine Sodium
Product Information
| CAS | 1955/6/1 |
| Name | Liothyronine Sodium |
| Molecular Formula | C15H11I3NNaO4 |
| Molecular Weight | 672.96 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00002594 |
| SMILES | C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)[O-])N)I)I)O.[Na+] |
| InChIKey | SBXXSUDPJJJJLC-YDALLXLXSA-M |
| InChI | InChI=1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4，6，12，20H，5，19H2，(H，21，22);/q;+1/p-1/t12-;/m0./s1 |
| PubChem CID | 23666110 |
| Target Point | Thyroid Hormone Receptor(TRβ1) |
| Passage | Endocrinology & Hormones |
| Background | It is a potent thyroid hormone that binds to and activates the β1 thyroid hormone receptor (TRβ1). |
| Biological Activity | Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ， respectively[1-3]. |
| In Vitro | Liothyronine(T3，100 nM)sodium stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. Liothyronine sodium binds to human β1 thyroid hormone receptor(hTRβ1)，and changes its conformation. Liothyronine sodium promotes growth，induces differentiation and regualtes metabolic effects[2]. |
| Cell Experiment | Thyroid hormone depleted(Td)serum is prepared. The growth of hepatocarcinoma cells in methylcellulose is performed. To determine the effect of Liothyronine(T3)on the growth of cells，cells are plated at a density of 3 × 104 cells/60 mm dish on day 0，and incubated in medium containing 5% regular serum，5% Td or 5% Td and 100 nM T3. The colony formation in methylcellulose is scored 3 weeks after initial plating[1]. |
| Data Literature Source | [1]. Lin KH，et al. Stimulation of proliferation by 3，3'，5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. [2]. Bhat MK，et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3，3'，5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. [3]. Hiroaki Shiohara，et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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