{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > CWHM-12CAS：1564286-55-0
Molecular Formula：C26H32BrN5O6
Molecular Weight：590.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 1564286-55-0 |
| Name | CWHM-12 |
| Molecular Formula | C26H32BrN5O6 |
| Molecular Weight | 590.47 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CC(C)(C)C1=CC(=CC(=C1)C(CC(=O)O)NC(=O)CNC(=O)C2=CC(=CC(=C2)O)NC3= NCC(CN3)O)Br |
| InChIKey | YDHAGPCZRFQPOI-NRFANRHFSA-N |
| InChI | InChI=1S/C26H32BrN5O6/c1-26(2，3)16-4-14(5-17(27)8-16)21(10-23(36)37)32-22(35)13-28- 24(38)15-6-18(9-19(33)7-15)31-25-29-11-20(34)12-30-25/h4-9，20-21，33-34H， 10-13H2，1-3H3，(H，28，38)(H，32，35)(H，36，37)(H2，29，30，31)/t21-/m0/s1 |
| PubChem CID | 72949858 |
| Target Point | Integrin(αvβ8/αvβ3/αvβ6/αvβ1) |
| Passage | Cytoskeleton |
| Background | CWHM-12 is a potent inhibitor of αV integrin, inhibiting αvβ8, αvβ3, αvβ6 and αvβ1. |
| Biological Activity | CWHM-12 is a potent inhibitor of αV integrins with IC50s of 0.2， 0.8， 1.5， and 1.8 nM for αvβ8， αvβ3， αvβ6， and αvβ1.[1-2] |
| IC50 | IC50: 0.2 nM (αvβ8)， 0.8 nM (αvβ3)， 1.5 nM (αvβ6)， 1.8 nM (αvβ1)， 61 nM (αvβ5)[1] |
| Data Literature Source | [1]. Henderson NC， et al. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24. [2]. Basta J， Robbins L， Stout L， Prinsen MJ， Griggs DW， Rauchman M. Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury. Physiol Rep. 2020;8(7):e14329. |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
