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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > H-89CAS：127243-85-0
Molecular Formula：C20H20BrN3O2S
Molecular Weight：446.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 127243-85-0 |
| Name | H-89 |
| Molecular Formula | C20H20BrN3O2S |
| Molecular Weight | 446.36 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00214120 |
| SMILES | C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNC/C=C/C3=CC=C(C=C3)Br |
| InChIKey | ZKZXNDJNWUTGDK-NSCUHMNNSA-N |
| InChI | InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25，26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10，12，15，22，24H，11，13-14H2/b3-2+ |
| PubChem CID | 449241 |
| Target Point | PKA |
| Passage | Stem Cells; Protein Tyrosine Kinase/RTK |
| Background | H-89 is A potent and selective CAMP-dependent protein kinase A inhibitor. |
| Biological Activity | H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM and has weak inhibition on PKG， PKC， Casein Kinase， and others kinases.[1-3] |
| IC50 | IC50: 48 nM (protein kinase A)[1-3] |
| Data Literature Source | [1]. Chijiwa T， et al. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase， N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89)， of PC12D [2]. Blazev R， et al. Effects of the PKA inhibitor H-89 on excitation-contraction coupling in skinned and intact skeletal muscle fibres. J Muscle Res Cell Motil. 2001;22(3):277-86. [3]. Hosseini-Zare MS， et al. Effects of pentoxifylline and H-89 on epileptogenic activity of bucladesine in pentylenetetrazol-treated mice. Eur J Pharmacol. 2011 Nov 30;670(2-3):464-70. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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