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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Loureirin BCAS：119425-90-0
Molecular Formula：C18H20O5
Molecular Weight：316.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Solid
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| CAS | 119425-90-0 |
| Name | Loureirin B |
| Molecular Formula | C18H20O5 |
| Molecular Weight | 316.35 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | HPLC≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD07781421 |
| SMILES | COC1=CC(=C(C(=C1)OC)CCC(=O)C2=CC=C(C=C2)O)OC |
| InChIKey | ZPFRAPVRYLGYEC-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H20O5/c1-21-14-10-17(22-2)15(18(11-14)23-3)8-9-16(20)12-4-6-13(19)7-5-12/h4-7，10-11，19H，8-9H2，1-3H3 |
| PubChem CID | 189670 |
| Target Point | PAI-1 |
| Passage | Metabolic Enzyme&Protease |
| Background | Loureirin B is an inhibitor of PAI-1 and has antidiabetic activity. |
| Biological Activity | Loureirin B， a flavonoid extracted from Dracaena cochinchinensis， is an inhibitor of plasminogen activator inhibitor-1 (PAI-1)， with an IC50 of 26.10?μM; Loureirin B also inhibits KATP， the phosphorylation of ERK and JNK， and has anti-diabetic activity.[1-4] |
| Data Literature Source | [1]. Sha Y， et al. Loureirin B promotes insulin secretion through inhibition of KATP channel and influx of intracellular calcium. J Cell Biochem. 2017 Aug 17. [2]. He T， et al. Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway. Cell Physiol Biochem. 2015;37(2):666-76. [3]. Bai X， et al. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway. Exp Dermatol. 2015 May;24(5):355-60. [4]. Yu Jiang， et al. Bioactivity-Guided Fractionation of the Traditional Chinese Medicine Resina Draconis Reveals Loureirin B as a PAI-1 Inhibitor. Evidence-Based Complementary and Alternative Medicine |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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