Polygalasaponin XXXI
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Cat.No：IP5460 Solarbio
CAS：79103-90-5
Storage：Powder:-20℃，2 years
Purity：HPLC≥95%
Appearance：Solid
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > Polygalasaponin XXXI
Product Information
| CAS | 79103-90-5 |
| Name | Polygalasaponin XXXI |
| Molecular Formula | C75H112O36 |
| Molecular Weight | 1589.67 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥95% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years |
| MDL | MFCD29904545 |
| SMILES | CC1C(C(C(C(O1)OC(=O)C23CCC(CC2C4=CCC5C(C4(CC3)CO)(CCC6C5(CC(C(C6(C)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)C)C)(C)C)OC8C(C(C(C(O8)C)OC9C(C(C(CO9)O)OC1C(C(C(CO1)O)O)O)O)OC1C(C(CO1)(CO)O)O)O)O)OC(=O)C=CC1=CC(=C(C(=C1)OC)OC)OC |
| InChIKey | HDLNHPZHTNFCNP-JJEFWQELSA-N |
| InChI | InChI=1S/C75H112O36/c1-31-53(105-44(82)14-11-33-21-39(96-8)56(98-10)40(22-33)97-9)50(88)58(109-64-52(90)57(108-66-59(91)75(95，29-78)30-101-66)54(32(2)102-64)106-62-51(89)55(38(81)27-100-62)107-61-48(86)45(83)37(80)26-99-61)65(103-31)111-68(94)73-18-17-69(3，4)23-35(73)34-12-13-42-70(5)24-36(79)60(110-63-49(87)47(85)46(84)41(25-76)104-63)72(7，67(92)93)43(70)15-16-71(42，6)74(34，28-77)20-19-73/h11-12，14，21-22，31-32，35-38，41-43，45-55，57-66，76-81，83-91，95H，13，15-20，23-30H2，1-10H3，(H，92，93)/b14-11+/t31-，32+，35+，36+，37+，38-，41-，42-，43-，45+，46-，47+，48-，49-，50+，51-，52-，53+，54+，55+，57+，58-，59+，60+，61+，62+，63+，64+，65+，66+，70-，71-，72+，73+，74+，75-/m1/s1 |
| PubChem CID | 10701737 |
| Target Point | Others |
| Passage | Others |
| Background | It is an active component of the adjuvant in intranasal influenza HA vaccine. |
| Biological Activity | Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection[1]. |
| In Vitro | Polygalasaponin XXXI (Onjisaponin F) also enhances anti-HA IgA and IgG Ab titers in the nasal wash， whereas Onjisaponins E and G enhances only anti-HA IgA Ab titer significantly. Polygalasaponin XXXI can induce protective immunity against intranasal infection by influenza virus[1].Polygalasaponin XXXI (Onjisaponin F) (1 or 10 μg/mL) also induces ChAT mRNA level in rat basal forebrain cells[2]. |
| In Vivo | Intranasal vaccination with Polygalasaponin XXXI (Onjisaponin F) inhibits proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice[1]. |
| Data Literature Source | [1]. T Nagai，et al. Onjisaponins，From the Root of Polygala Tenuifolia Willdenow，as Effective Adjuvants for Nasal Influenza and Diphtheria-Pertussis-Tetanus Vaccines. Vaccine. 2001 Sep 14;19(32):4824-34. [2]. T Yabe，et al. Induction of NGF Synthesis in Astrocytes by Onjisaponins of Polygala Tenuifolia，Constituents of Kampo (Japanese Herbal) Medicine，Ninjin-yoei-to. Phytomedicine. 2003 Mar;10(2-3):106-14. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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