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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > SC-514CAS：354812-17-2
Molecular Formula：C9H8N2OS2
Molecular Weight：224.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 354812-17-2 |
| Name | SC-514 |
| Molecular Formula | C9H8N2OS2 |
| Molecular Weight | 224.3 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00206459 |
| SMILES | C1=CSC=C1C2=CC(=C(S2)C(=O)N)N |
| InChIKey | BMUACLADCKCNKZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H，10H2，(H2，11，12) |
| PubChem CID | 2807869 |
| Target Point | IKK2 |
| Passage | NF-κB |
| Background | SC-514 is a selective IKK-2 inhibitor. |
| Biological Activity | SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM)， which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.[1-2] |
| Data Literature Source | [1]. Kishore N， et al. A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem. 2003 Aug 29;278(35):32861-71. [2]. Tse AK， et al. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biol. 2017 Apr;11:562-576. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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