BAY 61-3606
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Cat.No：IB4460 Solarbio
CAS：732983-37-8
Molecular Formula：C20H18N6O3
Molecular Weight：390.4
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：Solid
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PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Oscillating Mixing & Stirring & Dispersing Instrument
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > BAY 61-3606
Product Information
| CAS | 732983-37-8 |
| Name | BAY 61-3606 |
| Molecular Formula | C20H18N6O3 |
| Molecular Weight | 390.4 |
| Solubility | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years |
| SMILES | COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC |
| InChIKey | JWQOJVOKBAAAAR-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H，1-2H3，(H2，21，27)(H，23，24，25) |
| PubChem CID | 10200390 |
| Target Point | Syk |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | BAY 61-3606 is a competitive and reversible Syk selective inhibitor of ATP， and has no inhibition on Btk， Fyn， Itk， Lyn and Src. |
| Biological Activity | BAY 61-3606 is an orally available， ATP-competitive， reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM[1]. BAY 61-3606 reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell[2]. BAY 61-3606 induces a large decrease of Syk phosphorylation in K-rn cell lysates[3]. Bay 61-3606 sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells[4]. |
| IC50 | Ki: 7.5 nM (Syk)[1].IC50: 10 nM (Syk)[1] |
| Data Literature Source | [1]. Yamamoto N，et al. The orally available spleen tyrosine kinase inhibitor 2-[7-(3，4-dimethoxyphenyl)-imidazo[1，2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther. 2 [2]. Gioia R，et al. Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells. Blood. 2011 Aug 25;118(8):2211-21. [3]. Tümmler C，et al. SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro. Cancers (Basel). 2019 Feb 10;11(2). pii: E202. [4]. Kim SY，et al. Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells. PLoS One. 2015 Dec 31;10(12):e0146073. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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