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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > PF-2771CAS：2070009-55-9
Molecular Formula：C29H36ClN5O4
Molecular Weight：554.08
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 2070009-55-9 |
| Name | PF-2771 |
| Molecular Formula | C29H36ClN5O4 |
| Molecular Weight | 554.08 |
| Solubility | Soluble in DMSO ≥3mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CC(C)OC1=C(C=C(C=C1)C(=O)NC(CC2=CC=C(C=C2)C3=CN(C(=N3)C(=O)C)C)CNC(=O)CN(C)C)Cl |
| InChIKey | VHBJNUOZEQTSNN-QHCPKHFHSA-N |
| InChI | InChI=1S/C29H36ClN5O4/c1-18(2)39-26-12-11-22(14-24(26)30)29(38)32-23(15-31-27(37)17-34(4)5)13-20-7-9-21(10-8-20)25-16-35(6)28(33-25)19(3)36/h7-12，14，16，18，23H，13，15，17H2，1-6H3，(H，31，37)(H，32，38)/t23-/m0/s1 |
| PubChem CID | 118704759 |
| Target Point | Kinesin(CENP-E) |
| Passage | Cytoskeleton |
| Background | PF-2771 is a selective inhibitor of centromere protein E (CENP-E) with antitumor activity. |
| Biological Activity | PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor， inhibiting CENP-E motor activity with an IC50 of 16.1 nM; PF-2771 is used as an anticancer agent.[1] |
| Data Literature Source | [1]. Kung PP， et al. Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer. Mol Cancer Ther. 2014 Aug;13(8):2104-15. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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