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My CartCAS：32222-06-3
Molecular Formula：C27H44O3
Molecular Weight：416.64
Storage：Powder:-20℃，2 years
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 32222-06-3 |
| Name | Calcitriol |
| Molecular Formula | C27H44O3 |
| Molecular Weight | 416.64 |
| Solubility | Soluble in DMSO/Ethanol ≥10mg/mL(This product is not stable in solution, it is recommended that you use it now) |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years |
| MDL | MFCD00867079 |
| SMILES | CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C |
| InChIKey | GMRQFYUYWCNGIN-NKMMMXOESA-N |
| InChI | InChI=1S/C27H44O3/c1-18(8-6-14-26(3，4)30)23-12-13-24-20(9-7-15-27(23，24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11，18，22-25，28-30H，2，6-9，12-17H2，1，3-5H3/b20-10+，21-11-/t18-，22-，23-，24+，25+，27-/m1/s1 |
| PubChem CID | 5280453 |
| Target Point | VD/VDR |
| Passage | Others |
| Background | Calcitriol is a non-selective activator of vitamin D receptor. |
| Biological Activity | Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.[1-4] |
| Data Literature Source | [1]. Wang G， et al. Calcitriol Inhibits Cervical Cancer Cell Proliferation Through Downregulation of HCCR1 Expression. Oncol Res. 2014;22(5-6):301-9. [2]. Santos-Martínez N， et al. Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: a potential new therapeutic approach. BMC Cancer. 2014 Mar 29;14:230. [3]. Dong J， et al. Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor. Kidney Int. 2013 Jul;84(1):54-63. [4]. Chou CL， et al. Beneficial effects of calcitriol on hypertension， glucose intolerance， impairment of endothelium-dependent vascular relaxation， and visceral adiposity in fructose-fed hypertensive rats. PLoS One. 2015 Mar 16;10(3):e0119843. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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