Aldoxorubicin
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Cat.No：IA6520 Solarbio
CAS：1361644-26-9
Molecular Formula：C37H42N4O13
Molecular Weight：750.75
Storage：Powder:-20℃，2 years
Purity：≥98%
Appearance：Solid
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > Aldoxorubicin
Product Information
| CAS | 1361644-26-9 |
| Name | Aldoxorubicin |
| Molecular Formula | C37H42N4O13 |
| Molecular Weight | 750.75 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic)(This product is not stable in solution, it is recommended that you use it now) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years |
| MDL | MFCD15146982 |
| SMILES | C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(/C(=N/NC(=O)CCCCCN6C(=O)C=CC6=O)/CO)O)N)O |
| InChIKey | OBMJQRLIQQTJLR-USGQOSEYSA-N |
| InChI | InChI=1S/C37H42N4O13/c1-17-32(46)20(38)13-27(53-17)54-22-15-37(51，23(16-42)39-40-24(43)9-4-3-5-12-41-25(44)10-11-26(41)45)14-19-29(22)36(50)31-30(34(19)48)33(47)18-7-6-8-21(52-2)28(18)35(31)49/h6-8，10-11，17，20，22，27，32，42，46，48，50-51H，3-5，9，12-16，38H2，1-2H3，(H，40，43)/b39-23+/t17-，20-，22-，27-，32+，37-/m0/s1 |
| PubChem CID | 9810709 |
| Target Point | Others |
| Passage | Others |
| Background | It is a compound with anti-tumor activity. |
| Biological Activity | Aldoxorubicin (INNO-206) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor)， which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models.[1-4] |
| Data Literature Source | [1]. Eric Sanchez， et al. Anti-Myeloma Effects of the Novel Anthracycline Derivative INNO-206. Clin Cancer Res.2012 18; 3856. [2]. Kratz， F. INNO-206 (DOXO-EMCH)， an Albumin-Binding Prodrug of Doxorubicin Under Development for Phase II Studies. Current Bioactive Compounds， 2011， 7(1): 33-38(6) [3]. Graeser R， et al. INNO-206， the (6-maleimidocaproyl hydrazone derivative of doxorubicin)， shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model. Invest New Drugs. 2010 F [4]. Walker L， et al. Cell penetrating peptides fused to a thermally targeted biopolymer drug carrier improve the delivery and antitumor efficacy of an acid-sensitive doxorubicin derivative. Int J Pharm. 2012 Oct 15;436(1-2):825-32. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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