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My CartCAS：768-94-5
Molecular Formula：C10H17N
Molecular Weight：151.25
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 768-94-5 |
| Name | Amantadine |
| Molecular Formula | C10H17N |
| Molecular Weight | 151.25 |
| Solubility | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic or Water bath) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years |
| MDL | MFCD00074732 |
| SMILES | C1C2CC3CC1CC(C2)(C3)N |
| InChIKey | DKNWSYNQZKUICI-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H，1-6，11H2 |
| PubChem CID | 2130 |
| Target Point | Influenza Virus |
| Passage | Anti-infection |
| Background | Amantadine is an effective antiviral compound against influenza A (influenza A) virus. Amantadine can inhibit ion channels such as NMDA and M2. |
| Biological Activity | Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2， and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease， postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6]. |
| IC50 | CDK2.Bcl-2.Bax |
| Data Literature Source | [1]. Suzuki H，et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. [2]. Hubsher G，et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099. [3]. Donald F Smee，et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. [4]. Fink K，et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. [5]. Zhang J，et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85. [6]. Lan Z，et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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