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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > BrequinarCAS：96187-53-0
Molecular Formula：C23H15F2NO2
Molecular Weight：375.37
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 96187-53-0 |
| Name | Brequinar |
| Molecular Formula | C23H15F2NO2 |
| Molecular Weight | 375.37 |
| Solubility | Soluble in DMSO ≥3mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00866437 |
| SMILES | CC1=C(C2=C(C=CC(=C2)F)N=C1C3=CC=C(C=C3)C4=CC=CC=C4F)C(=O)O |
| InChIKey | PHEZJEYUWHETKO-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H，1H3，(H，27，28) |
| PubChem CID | 57030 |
| Target Point | dihydroorotate dehydrogenase (DHODH) ;Antiviral |
| Passage | Metabolic Enzyme&Protease;Anti-infection |
| Background | Brequinar is a potent dihydroorotate dehydrogenase (DHODH) inhibitor， as well as a broad-spectrum antiviral compound with anti-SarS2 activity. |
| Biological Activity | Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. Brequinar also has an anti-SARS2 activity.[1-5] |
| Data Literature Source | [1]. Schnellrath LC， et al. Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture. Int J Antimicrob Agents. 2011 Nov;38(5):435-41. [2]. Qing M， et al. Characterization of dengue virus resistance to brequinar in cell culture. Antimicrob Agents Chemother. 2010 Sep;54(9):3686-95. [3]. Xu X， et al. In vitro and in vivo mechanisms of action of the antiproliferative and immunosuppressive agent， brequinar sodium. J Immunol. 1998 Jan 15;160(2):846-53. [4]. Zeping Zuo， et al. Bifunctional Naphtho[2，3-d][1，2，3]triazole-4，9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production. J Med Chem. 2020 Jun 4. [5]. David C Schultz， et al. Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2. Nature. 2022 Feb 7. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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