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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > (R)-CR8CAS：294646-77-8
Molecular Formula：C24H29N7O
Molecular Weight：431.53
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 294646-77-8 |
| Name | (R)-CR8 |
| Molecular Formula | C24H29N7O |
| Molecular Weight | 431.53 |
| Solubility | Soluble in DMSO ≥10mg/mL(Need ultrasonic or Water bath) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18785641 |
| SMILES | CCC(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C=C3)C4=CC=CC=N4 |
| InChIKey | HOCBJBNQIQQQGT-LJQANCHMSA-N |
| InChI | InChI=1S/C24H29N7O/c1-4-19(14-32)28-24-29-22(21-23(30-24)31(15-27-21)16(2)3)26-13-17-8-10-18(11-9-17)20-7-5-6-12-25-20/h5-12，15-16，19，32H，4，13-14H2，1-3H3，(H2，26，28，29，30)/t19-/m1/s1 |
| PubChem CID | 10224714 |
| Target Point | CDK1/2/5/7/9 |
| Passage | Cell Cycle |
| Background | (R) -CR8 is a potent inhibitor of CDK1/2/5/7/9. |
| Biological Activity | (R) - CR8 (CR8)，a second-generation analog of Roscovitine，is a potent CDK1/2/5/7/9 inhibitor. (R) - CR8 inhibits CDK1/cyclin B (IC50=0.09 μM)，CDK2/cyclin A (0.072 μM)，CDK2/cyclin E (0.041 μM)，CDK5/p25 (0.11 μM)，CDK7/cyclin H (1.1 μM)，CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R) - CR8 induces apoptosis and has neuroprotective effect.(R)-CR8 acts as a molecular glue degrader that depletes cyclin K[1-3]. |
| Data Literature Source | [1]. Bettayeb K，et al. CR8，a potent and selective，roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. [2]. Kabadi SV，et al. CR8，a novel inhibitor of CDK，limits microglial activation，astrocytosis，neuronal loss，and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13. [3]. S abicki M，et al. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K [published online ahead of print，2020 Jun 3]. Nature. 2020;10.1038/s41586-020-2374-x. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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