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My CartCAS：75498-96-3
Molecular Formula：C16H20N7O7S3Na
Molecular Weight：541.56
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 75498-96-3 |
| Name | Cefminox Sodium |
| Molecular Formula | C16H20N7O7S3Na |
| Molecular Weight | 541.56 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00941387 |
| SMILES | CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)(NC(=O)CSCC(C(=O)O)N)OC)SC2)C(=O)[O-].[Na+] |
| InChIKey | SBIDXLKJYJVQOE-YNJMIPHHSA-M |
| InChI | InChI=1S/C16H21N7O7S3.Na/c1-22-15(19-20-21-22)33-4-7-3-32-14-16(30-2，13(29)23(14)10(7)12(27)28)18-9(24)6-31-5-8(17)11(25)26;/h8，14H，3-6，17H2，1-2H3，(H，18，24)(H，25，26)(H，27，28);/q;+1/p-1/t8-，14-，16+;/m1./s1 |
| PubChem CID | 23663397 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Cefminox sodium is a kind of cephalomycin and has a broad spectrum of antibacterial activity. Cefminox sodium is a double agonist for prostacyclin receptor and PPARγ. |
| Biological Activity | Cefminox sodium (MT-141) is a semisynthetic cephamycin， which exhibits a broad spectrum of antibacterial activity[1]. Cefminox sodium (MT-141) also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ， upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium (MT-141) also prevents pulmonary arterial hypertension[2]. |
| IC50 | PPARγ.IP Receptor. Bacterial |
| Data Literature Source | [1]. Inouye S，et al. In vitro and in vivo antibacterial activities of MT-141，a new semisynthetic cephamycin，compared with those of five cephalosporins. Antimicrob Agents Chemother. 1984 Nov;26(5):722-9. [2]. Xia J，et al. Cefminox，a Dual Agonist of Prostacyclin Receptor and Peroxisome Proliferator-Activated Receptor-Gamma Identified by Virtual Screening，Has Therapeutic Efficacy against Hypoxia-Induced Pulmonary Hypertension in Rats. Front Pharmacol. 2018 Feb 23;9:134. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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