CAS:1005334-57-5
Storage:Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
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CVT-10216CAS:1005334-57-5
Storage:Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
CAS | 1005334-57-5 |
English Name | CVT-10216 |
Molecular Formula | C24H19NO7S |
Molecular Weight | 465.48 |
Solubility | Soluble in DMSO ≥2mg/mL(Need ultrasonic or Water bath) |
Purity | ≥98% |
Appearance | White to off-white Solid |
Storage | Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
MDL | MFCD18072197 |
SMILES | CS(=O)(=O)NC1=CC=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)OCC4=CC(=CC=C4)C(=O)O |
InChIKey | YYOOFJZTRCPVFD-UHFFFAOYSA-N |
InChI | InChI=1S/C24H19NO7S/c1-33(29,30)25-18-7-5-16(6-8-18)21-14-32-22-12-19(9-10-20(22)23(21)26)31-13-15-3-2-4-17(11-15)24(27)28/h2-12,14,25H,13H2,1H3,(H,27,28) |
PubChem CID | 23661666 |
Target Point | aldehyde dehydrogenase (ALDH1/2) |
Passage | Metabolic Enzyme&Protease |
Background | CVT-10216 is a highly selective reversible aldehyde dehydrogenase 2 (ALDH-2) inhibitor that also has ALDH-1 inhibition. |
Biological Activity | CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects[1]. |
IC50 | IC50: 29nM(ALDH-2)[1] |
In Vivo | CVT-10216(intraperitoneal injection; 3.75,7.5,or 15 mg/kg)exhibits a increase in social interaction as a dose-dependent manner,punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats[1]. |
Data Literature Source | [1]. Overstreet DH,et al. A selective ALDH-2 inhibitor reduces anxiety in rats.Pharmacol Biochem Behav. 2009 Dec;94(2):255-61. |
Unit | Bottle |
Specification | 1mg |