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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > 2,4-Diamino-6-hydroxypyrimidineCAS：1956/6/4
Molecular Formula：C4H6N4O
Molecular Weight：126.12
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to light yellow Solid
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| CAS | 1956/6/4 |
| Name | 2,4-Diamino-6-hydroxypyrimidine |
| Molecular Formula | C4H6N4O |
| Molecular Weight | 126.12 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Off-white to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00043013 |
| SMILES | C1=C(N=C(NC1=O)N)N |
| InChIKey | SWELIMKTDYHAOY-UHFFFAOYSA-N |
| InChI | InChI=1S/C4H6N4O/c5-2-1-3(9)8-4(6)7-2/h1H，(H5，5，6，7，8，9) |
| PubChem CID | 135408763 |
| Target Point | GTP cyclohydrolase I |
| Passage | Cell Cycle |
| Background | 2，4-Diamino-6-hydroxypyrimidine is a specific type I guanylase (GTP cyclohydrolase I; A rate-limiting enzyme in de novo protein synthesis， which inhibits BH4 synthesis and NO production. |
| Biological Activity | 2，4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis). 2，4-Diamino-6-hydroxypyrimidine blocks Tetrahydrobiopterin (BH4) synthesis and suppresses NO production[1-2]. |
| Data Literature Source | [1]. Sung YJ，et al. 2，4-Diamino-6-hydroxypyrimidine，an inhibitor of GTP cyclohydrolase I，suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol. 1994 Feb;16(2):101-8. [2]. Kazuhisa Ikemoto，et al. 2，4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner. Biochim Biophys Acta. Jul-Aug 2008;1780(7-8):960-5. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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