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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > D-64131CAS：74588-78-6
Molecular Formula：C16H13NO2
Molecular Weight：251.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 74588-78-6 |
| Name | D-64131 |
| Molecular Formula | C16H13NO2 |
| Molecular Weight | 251.28 |
| Solubility | Soluble in DMSO ≥3mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD04039791 |
| SMILES | COC1=CC2=C(C=C1)NC(=C2)C(=O)C3=CC=CC=C3 |
| InChIKey | ICMIJSRDISNKOC-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H13NO2/c1-19-13-7-8-14-12(9-13)10-15(17-14)16(18)11-5-3-2-4-6-11/h2-10，17H，1H3 |
| PubChem CID | 3921152 |
| Target Point | Microtubule/Tubulin |
| Passage | Cytoskeleton |
| Background | D-64131 is a tubulin polymerization inhibitor that competitively binds alpha-β-tubulin with colchicine. |
| Biological Activity | D-64131 is an orally active tubulin inhibitor， with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research[1][2]. |
| IC50 | IC50: 0.53 μM (tubulin polymerization)[2] |
| Data Literature Source | [1]. Thomas Beckers，et al. 2-Aroylindoles，a novel class of potent，orally active small molecule tubulin inhibitors. Cancer Research (2002)，62(11)，3113-3119. [2]. S Mahboobi，et al. Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory，antimitotic agents. J Med Chem. 2001 Dec 20;44(26):4535-53. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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