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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > DerazantinibCAS：1234356-69-4
Molecular Formula：C29H29FN4O
Molecular Weight：468.57
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1234356-69-4 |
| Name | Derazantinib |
| Molecular Formula | C29H29FN4O |
| Molecular Weight | 468.57 |
| Solubility | Soluble in DMSO ≥3mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30532770 |
| SMILES | COCCNCCC1=CC(=CC=C1)NC2=NC=C3C[C@H](C4=CC=CC=C4C3=N2)C5=CC=CC=C5F |
| InChIKey | KPJDVVCDVBFRMU-AREMUKBSSA-N |
| InChI | InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24-10-4-5-12-27(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12，17，19，26，31H，13-16，18H2，1H3，(H，32，33，34)/t26-/m1/s1 |
| PubChem CID | 46834118 |
| Target Point | FGFR |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Derazantinib is an FGFR inhibitor that also inhibits RET， DDR2， PDGFRβ， VEGFR， and KIT. |
| Biological Activity | Derazantinib (ARQ-087) is an ATP competitive and orally activeFGFR inhibitor (IC50s: 1.8 nM for FGFR2， 4.5 nM for FGFR1 and 3 nM). Derazantinib inhibits FGFR phosphorylation. Derazantinib inhibits tumor growth in multiple xenograft models.[1-2] |
| Data Literature Source | [1]. Hall TG， et al. Preclinical Activity of ARQ-087， a Novel Inhibitor Targeting FGFR Dysregulation. PLoS One. 2016 Sep 14;11(9):e0162594. [2]. Balek L， et al. ARQ-087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1， FGFR2 and FGFR3. Bone. 2017 Dec;105:57-66. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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