As a protein denaturant, it can dissolve some insoluble or denatured proteins; It can also be used for the initial folding of active proteins or enzymes.

It was used as a strong denaturant in experiments to extract total RNA from cells. Guanidine hydrochloride solution can dissolve proteins, leading to the destruction of cell structure and secondary structure of nuclear protein, which dissociates from nucleic acid. It is also able to sufficiently inhibit ribonuclease activity in cells and whole tissues. Because of its biological destructive properties, buffers containing guanidine hydrochloride or guanidine thiocyanate are often called dissociative buffers.

This product is a ready-to use 5M guanidine hydrochloride solution.

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