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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > HycanthoneCAS：3105-97-3
Molecular Formula：C20H24N2O2S
Molecular Weight：356.48
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥95%
Appearance：Yellow to orange Soild
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| CAS | 3105-97-3 |
| Name | Hycanthone |
| Molecular Formula | C20H24N2O2S |
| Molecular Weight | 356.48 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥95% |
| Appearance | Yellow to orange Soild |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00083383 |
| InChIKey | MFZWMTSUNYWVBU-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H24N2O2S/c1-3-22(4-2)12-11-21-16-10-9-14(13-23)20-18(16)19(24)15-7-5-6-8-17(15)25-20/h5-10，21，23H，3-4，11-13H2，1-2H3 |
| PubChem CID | 3634 |
| Target Point | DNA/RNA Synthesis;Topoisomerase;Parasite |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Anti-infection |
| Background | Hycanthone is a DNA intercalator that inhibits RNA synthesis as well as DNA topoisomerase I and II. Hycanthone inhibits nucleic acid biosynthesis and purinendonuclease 1 (APE1) by direct protein binding. Hycanthone has anti-schistosomiasis activity. |
| Biological Activity | Hycanthone is a thioxanthenone DNA intercalator and inhibits RNA synthesis as well as the DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a KD of 10 nM. Hycanthone is a bioactive metabolite of Lucanthone (HY-B2098) and has anti-schistosomal agent.[1-3] |
| Data Literature Source | [1]. Mamta D Naidu， et al. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One. 2011;6(9):e23679. [2]. Pica Mattoccia L， et al. Effect of hycanthone administered in vivo upon the incorporation of radioactive precursors into macromolecules of Schistosoma mansoni. Mol Biochem Parasitol. 1983 Jun;8(2):99-107. [3]. Hahon N， et al. Action of antischistosomal drugs， hycanthone and its analog 1A-4 N-oxide， on viral interferon induction. J Toxicol Environ Health. 1980 Jul;6(4):705-12. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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