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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > HMN-176CAS：173529-10-7
Molecular Formula：C20H18N2O4S
Molecular Weight：382.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 173529-10-7 |
| Name | HMN-176 |
| Molecular Formula | C20H18N2O4S |
| Molecular Weight | 382.43 |
| Solubility | Soluble in DMSO ≥3mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00945108 |
| SMILES | COC1=CC=C(C=C1)S(=O)(=O)N=C2C=CC=CC2=CC=C3C=CN(C=C3)O |
| InChIKey | MYEJOKLXXLVMPR-STNHEDLKSA-N |
| InChI | InChI=1S/C20H18N2O4S/c1-26-18-8-10-19(11-9-18)27(24，25)21-20-5-3-2-4-17(20)7-6-16-12-14-22(23)15-13-16/h2-15，23H，1H3/b17-7+，21-20+ |
| PubChem CID | 12134997 |
| Target Point | Polo-like Kinase (PLK) |
| Passage | Cell Cycle |
| Background | HMN-176， a derivative of diphenyl ethylene， can inhibit mitosis and interfere with plk1. |
| Biological Activity | HMN-176?is a stilbene derivative which inhibits mitosis， interfering with polo-like kinase-1 (plk1)， without significant effect on tubulin polymerization.[1-5] |
| Data Literature Source | [1]. DiMaio MA， et al. The small organic compound HMN-176 delays satisfaction of the spindle assembly checkpoint by inhibiting centrosome-dependent microtubule nucleation. Mol Cancer Ther. 2009 Mar;8(3):592-601. [2]. Medina-Gundrum L， et al. Investigation of HMN-176 anticancer activity in human tumor specimens in vitro and the effects of HMN-176 on differential gene expression. Invest New Drugs. 2005 Jan;23(1):3-9. [3]. Takagi M， et al. In vivo antitumor activity of a novel sulfonamide， HMN-214， against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite， HMN-176. Invest New Drugs. 2003 Nov;21(4):387-99. [4]. Tanaka H， et al. HMN-176， an active metabolite of the synthetic antitumor agent HMN-214， restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y. Cancer Res. 2003 Oct 15;63(20):6942-7. [5]. Garland LL， et al. A phase I pharmacokinetic study of HMN-214， a novel oral stilbene derivative with polo-like kinase-1-interacting properties， in patients with advanced solid tumors. Clin Cancer Res. 2006 Sep 1;12(17):5182-9. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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