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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > (±)-10-HydroxycamptothecinCAS：64439-81-2
Molecular Formula：C20H16N2O5
Molecular Weight：364.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 64439-81-2 |
| Name | (±)-10-Hydroxycamptothecin |
| Molecular Formula | C20H16N2O5 |
| Molecular Weight | 364.35 |
| Solubility | Soluble in DMSO ≥3mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 613-598-9 |
| MDL | MFCD00274425 |
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O |
| InChIKey | HAWSQZCWOQZXHI-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7，23，26H，2，8-9H2，1H3 |
| PubChem CID | 4330531 |
| Target Point | Topoisomerase |
| Passage | DNA Damage/DNA Repair |
| Background | (±)-10-Hydroxycamptothecin is an alkaloid that inhibits the activity of topoisomerase I and has broad spectrum antitumor activity. |
| Biological Activity | (±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.[1-3] |
| Data Literature Source | [1]. Liu SY， et al. Interaction of several nucleoside triphosphate analogues and 10-hydroxycamptothecin with human DNA topoisomerases. Cancer Res. 1989 Mar 15;49(6):1366-70. [2]. Ping YH， et al. Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. Oncol Rep. 2006 May;15(5):1273-9. [3]. Fan J， et al. Detection of apoptosis exposed to 10-hydroxycamptothecin in T24 human urinary bladder cancer cells. Zhonghua Wai Ke Za Zhi. 1999 Jan;37(1):57-9. |
| Unit | Bottle |
| Specification | 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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