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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > HSF1ACAS：1196723-93-9
Molecular Formula：C21H19N3O2S2
Molecular Weight：409.52
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1196723-93-9 |
| Name | HSF1A |
| Molecular Formula | C21H19N3O2S2 |
| Molecular Weight | 409.52 |
| Solubility | Soluble in DMSO ≥15mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22580417 |
| SMILES | CCC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=NN2C3=CC=CC=C3)C4=CC=CS4 |
| InChIKey | KJTITGSAONQVPY-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H19N3O2S2/c1-2-16-10-12-18(13-11-16)28(25，26)23-21-15-19(20-9-6-14-27-20)22-24(21)17-7-4-3-5-8-17/h3-15，23H，2H2，1H3 |
| PubChem CID | 44472508 |
| Target Point | HSF1 |
| Passage | Cell Cycle;Metabolic Enzyme&Protease |
| Background | HSF1A is a heat shock transcription factor 1 (HSF1) activator. |
| Biological Activity | HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1). HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding.[1-4] |
| Data Literature Source | [1]. Neef DW， et al. A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. Cell Rep. 2014 Nov 6;9(3):955-66. [2]. Neef DW， et al. Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. PLoS Biol. 2010 Jan 19;8(1):e1000291. [3]. Huang CY， et al. Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death. Cell Death Dis. 2016 Nov 3;7(11):e2455. [4]. Marcus Steinemann， et al. The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9580-9585. |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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