{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > MotesanibCAS：453562-69-1
Molecular Formula：C22H23N5O
Molecular Weight：373.45
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 453562-69-1 |
| Name | Motesanib |
| Molecular Formula | C22H23N5O |
| Molecular Weight | 373.45 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD10567689 |
| SMILES | CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C |
| InChIKey | RAHBGWKEPAQNFF-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12，26H，13-14H2，1-2H3，(H，24，25)(H，27，28) |
| PubChem CID | 11667893 |
| Target Point | VEGFR1/2/3 |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | Motesanib is an effective ATP Competitive inhibition of VEGFR1/2/3. |
| Biological Activity | Motesanib (AMG 706) is a potent ATP-competitive inhibitor of?VEGFR1/2/3?with?IC50s?of 2 nM/3 nM/6 nM， respectively， and has similar activity against Kit， and is appr 10-fold more selective for VEGFR than PDGFR and Ret.[1-3] |
| Data Literature Source | [1]. Polverino A， et al. AMG 706， an oral， multikinase inhibitor that selectively targets vascular endothelial growth factor， platelet-derived growth factor， and kit receptors， potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer R [2]. Kruser TJ， et al. Augmentation of radiation response by motesanib， a multikinase inhibitor that targets vascular endothelial growth factor receptors. Clin Cancer Res， 2010， 16(14)， 3639-3647. [3]. Coxon A， et al. Broad antitumor activity in breast cancer xenografts by motesanib， a highly selective， oral inhibitor of vascular endothelial growth factor， platelet-derived growth factor， and Kit receptors. Clin Cancer Res， 2009， 15(1)， 110-118. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
