OTSSP167
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Cat.No：IO0840 Solarbio
CAS：1431697-89-0
Molecular Formula：C25H28Cl2N4O2
Molecular Weight：487.42
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：Solid
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Colloidal Gold Reagent
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Allophycocyanin(APC)-Conjugated
CY Fluorescent-Conjugated
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
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MAPK
NF-κB
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TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
Others
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > OTSSP167
Product Information
| CAS | 1431697-89-0 |
| Name | OTSSP167 |
| Molecular Formula | C25H28Cl2N4O2 |
| Molecular Weight | 487.42 |
| Solubility | Soluble in --- |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years |
| MDL | MFCD23160047 |
| SMILES | CC(=O)C1=CN=C2C=CC(=NC2=C1NC3CCC(CC3)CN(C)C)C4=CC(=C(C(=C4)Cl)O)Cl |
| InChIKey | DKZYXHCYPUVGAF-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H28Cl2N4O2/c1-14(32)18-12-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-17-6-4-15(5-7-17)13-31(2)3/h8-12，15，17，33H，4-7，13H2，1-3H3，(H，28，29) |
| PubChem CID | 135398499 |
| Target Point | MELK |
| Passage | PI3K/Akt/mTOR |
| Background | OTSSP167 is an efficient MELK inhibitor. |
| Biological Activity | OTSSP167 (OTS167) is a highly potent and ATP-competitive MELK inhibitor with IC50 value of 0.41 nM.[1-4] |
| IC50 | IC50: 0.41 nM (MELK)[1-4] |
| Data Literature Source | [1]. Chung S， Suzuki H， Miyamoto T， et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. 2012 Dec 21. [2]. Li S， et al. Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in gastric cancer. Oncotarget. 2016 Feb 2;7(5):6266-80. [3]. Ji W， et al. OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLoS One. 2016 Apr 15;11(4):e0153518. [4]. Cho YS， et al. The crystal structure of MPK38 in complex with OTSSP167， an orally administrative MELK selective inhibitor. Biochem Biophys Res Commun. 2014 Apr 25;447(1):7-11. |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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