{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > Palomid 529CAS：914913-88-5
Molecular Formula：C24H22O6
Molecular Weight：406.43
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 914913-88-5 |
| Name | Palomid 529 |
| Molecular Formula | C24H22O6 |
| Molecular Weight | 406.43 |
| Solubility | Soluble in DMSO ≥10mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 806-313-6 |
| MDL | MFCD18633224 |
| SMILES | CC(C1=CC2=C(C=C1)C3=CC(=C(C=C3OC2=O)OCC4=CC=C(C=C4)OC)OC)O |
| InChIKey | YEAHTLOYHVWAKW-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H22O6/c1-14(25)16-6-9-18-19-11-22(28-3)23(12-21(19)30-24(26)20(18)10-16)29-13-15-4-7-17(27-2)8-5-15/h4-12，14，25H，13H2，1-3H3 |
| PubChem CID | 11998575 |
| Target Point | mTOR |
| Passage | PI3K/Akt/mTOR |
| Background | Palomid 529 is an effective mTORC1 and mTORC2 complex inhibitor. |
| Biological Activity | Palomid 529 is a potent inhibitor of mTORC1 and mTORC2 complexes.[1-3] |
| Data Literature Source | [1]. Xue Q， et al. Palomid 529， a novel small-molecule drug， is a TORC1/TORC2 inhibitor that reduces tumor growth， tumor angiogenesis， and vascular permeability. Cancer Res， 2008， 68(22)， 9551-9557. [2]. Weinberg MA， et al. RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes. Anticancer Drugs. 2016 Jul;27(6):475-87. [3]. Gravina GL， et al. The TORC1/TORC2 inhibitor， Palomid 529， reduces tumor growth and sensitizes to docetaxel andcisplatin in aggressive and hormone-refractory prostate cancer cells. Endocr Relat Cancer. 2011 Jul 1;18(4):385-400. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
