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Your Position: Home > Small Molecule Compounds > Dye & Probe > 2',3'-cGAMP-Cy5 conjugate
2',3'-cGAMP-Cy5 conjugate

Appearance:Solid

Storage:Store powder at -20℃ for 2 years, in solvent(mother liquid) at -20℃ for 1 month, -80℃ for 6 months.

Purity:≥95%

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2',3'-cGAMP-Cy5 conjugate
Cat.No：
IG4060
Brand：
Solarbio
SKU Tongzhou Beijing Haidian Beijing Wuhan Guangzhou
IG4060-100ug Inquiry Inquiry Inquiry Inquiry
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Product Information Related Products Related Paper COA Technical Q&A

2’,3’-cGAMP or cGAMP (Cyclic guanosine monophosphate"adenosine monophosphate) is produced in mammalian cells by cGAS (cGAMP synthase) from ATP and GTP upon cytosolic DNA stimulation. cGAMP produced by cGAS contains mixed phosphodiester linkages, with one between 2\’-OH of GMP and 5\’-phosphate of AMP and the other between 3\’-OH of AMP and 5\’-phosphate of GMP. 2’,3’-cGAMP is also referred to as "noncanonical" cGAMP due to the presence of the atypical 2’-5’ phosphodiester linkage between the guanosine and the adenosine. Similar to the canonical 3’,3’-cGAMP, 2’3’-cGAMP serves as a second messenger to activate innate immune responses by binding to STING (stimulator of IFN genes) and subsequently inducing the TBK1-IRF3-dependent production of IFN-β. This Cy5-labeled cGAMP provides an excellent probe for developing fluorescence-based assays and test for detecting cGAMP and monitoring its activity.

Remark：
These protocols are for reference only. Solarbio does not independently validate these methods.

Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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