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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > K-604 DihydrochlorideCAS：217094-32-1
Molecular Formula：C23H32Cl2N6OS3
Molecular Weight：575.64
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to light yellow Solid
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| CAS | 217094-32-1 |
| Name | K-604 Dihydrochloride |
| Molecular Formula | C23H32Cl2N6OS3 |
| Molecular Weight | 575.64 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30738203 |
| SMILES | CC1=CC(=C(C(=N1)SC)NC(=O)CN2CCN(CC2)CCSC3=NC4=CC=CC=C4N3)SC.Cl.Cl |
| InChIKey | DEKWEGUBUYKTAV-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H30N6OS3.2ClH/c1-16-14-19(31-2)21(22(24-16)32-3)27-20(30)15-29-10-8-28(9-11-29)12-13-33-23-25-17-6-4-5-7-18(17)26-23;;/h4-7，14H，8-13，15H2，1-3H3，(H，25，26)(H，27，30);2*1H |
| PubChem CID | 22272715 |
| Target Point | ACAT1 |
| Passage | Metabolic Enzyme/Protease |
| Background | K-604 dihydrochloride is A potent and selective Acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor. |
| Biological Activity | K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 μM.[1-2] |
| Data Literature Source | [1]. Ikenoya M， et al. A selective ACAT-1 inhibitor， K-604， suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis. 2007 Apr;191(2):290-7. [2]. Shibuya Y， et al. Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimers disease mouse and reduces human P301L-tau content at the presymptomatic stage. Neurobiol Aging. 2015 Jul;36(7):2248-2259. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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