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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Toceranib PhosphateCAS：874819-74-6
Molecular Formula：C22H28FN4O6P
Molecular Weight：494.46
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 874819-74-6 |
| Name | Toceranib Phosphate |
| Molecular Formula | C22H28FN4O6P |
| Molecular Weight | 494.46 |
| Solubility | Soluble in Water/DMSO ≥0.1mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years |
| EC | EINECS 639-691-4 |
| MDL | MFCD25372034 |
| SMILES | CC1=C(NC(=C1C(=O)NCCN2CCCC2)C)/C=C3/C4=C(C=CC(=C4)F)NC3=O.OP(=O)(O)O |
| InChIKey | AOORBROPMMRREB-HBPAQXCTSA-N |
| InChI | InChI=1S/C22H25FN4O2.H3O4P/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27;1-5(2，3)4/h5-6，11-12，25H，3-4，7-10H2，1-2H3，(H，24，29)(H，26，28);(H3，1，2，3，4)/b17-12-; |
| PubChem CID | 16034840 |
| Target Point | PDGFRβ;VEGFR2/KDR/Flk-1 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Toceranib phosphate is a multi-target receptor tyrosine kinase (RTK) inhibitor that inhibits PDGFRβ and Flk-1/KDR. |
| Biological Activity | Toceranib phosphate (SU11654 phosphate) is an orally active receptor tyrosine kinase (RTK) inhibitor， and it potently inhibits PDGFR， VEGFR， and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR， respectively. Toceranib phosphate (SU11654 phosphate) has antitumor and antiangiogenic activity， and used in the treatment of canine mast cell tumors .[1-4] |
| Data Literature Source | [1]. London CA， et al. Phase I dose-escalating study of SU11654， a small molecule receptor tyrosine kinase inhibitor， in dogs with spontaneous malignancies. Clin Cancer Res. 2003 Jul;9(7):2755-68. [2]. Halsey CH， et al. Development of an in vitro model of acquired resistance to toceranib phosphate (Palladia?) in canine mast cell tumor. BMC Vet Res. 2014 May 6;10:105. [3]. Mitchell L， et al. Clinical and immunomodulatory effects of toceranib combined with low-dose cyclophosphamide in dogs with cancer. J Vet Intern Med. 2012 Mar-Apr;26(2):355-62. [4]. London C， Mathie T， Stingle N， et al. Preliminary evidence for biologic activity of toceranib phosphate (Palladia(?)) in solid tumours. Vet Comp Oncol. 2012;10(3):194-205. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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