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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > NGP555CAS：1304630-27-0
Molecular Formula：C23H23FN4S
Molecular Weight：406.52
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1304630-27-0 |
| Name | NGP555 |
| Molecular Formula | C23H23FN4S |
| Molecular Weight | 406.52 |
| Solubility | Soluble in DMSO ≥3mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CCC1=CC(=C(C=C1C)C)NC2=NC(=CS2)C3=CC(=C(C=C3)N4C=C(N=C4)C)F |
| InChIKey | WDEKUGNKKOGFOA-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H23FN4S/c1-5-17-10-20(15(3)8-14(17)2)26-23-27-21(12-29-23)18-6-7-22(19(24)9-18)28-11-16(4)25-13-28/h6-13H，5H2，1-4H3，(H，26，27) |
| PubChem CID | 46853593 |
| Target Point | γ-secretase |
| Passage | Stem Cells;Neuronal Signaling |
| Background | NGP 555 is a small molecule regulator of gamma-secretase. |
| Biological Activity | NGP555 is a γ-secretase modulator. NGP555 Lowers the Amyloid Biomarker Aβ42.[1] |
| IC50 | γ-secretase[1] |
| Data Literature Source | [1]. Kounnas MZ， et al. NGP 555， a γ-Secretase Modulator， Lowers the Amyloid Biomarker， Aβ42， in Cerebrospinal Fluid while Preventing Alzheimers Disease Cognitive Decline in Rodents. Alzheimers Dement (N Y). 2017 Jan;3(1):65-73. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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