Rifampicin

Description:

Antibiotics, which can inhibit the synthesis of mature virion DNA and protein; It is a special inhibitor of bacterial ribonucleic acid polymerase.

Use and synthesis method:

Scientific research reagent, widely used in molecular biology, pharmacology and other scientific research. Rifampicin is a semi-synthetic broad-spectrum rifamycin antibiotic, which has antibacterial activity against many pathogenic microorganisms. The drug has obvious bactericidal effect on M. tuberculosis and some non-M. tuberculosis (including M. leprae, etc.) both inside and outside the host cell. Rifampicin has a good antibacterial effect on aerobic gram-positive bacteria, including staphylococcus enzyme producing strains and methicillin-resistant strains, Streptococcus pneumoniae, other streptococcus genera, Enterococcus genera, Listeria genera, anthrax bacillus, perfringens bacillus, diphtheria bacillus, anaerobic coccus, etc. It also has high antibacterial activity against aerobic gram-negative bacteria such as Neisseria meningitidis, Haemophilus influenzae and Neisseria gonorrhoea. Rifampin also has a good effect on Legionella, and has an inhibitory effect on chlamydia trachomatis, venereal lymphogranuloma and pectin fever. Bacteria are cross-resistant to rifamycin antibiotics. Rifampin binds firmly to the ? subunit of DNA-dependent RNA polymerase, which inhibits bacterial RNA synthesis and prevents the enzyme from linking to DNA, thus blocking the RNA transcription process and stopping DNA and protein synthesis.

Solubility:

100mg/ml can be dissolved directly with DMSO. If DMSO is used as the solvent to prepare the storage solution, the working solution is diluted with 0.2M PBS.

Storage conditions: -20℃, avoid light, moisture, sealed and dry.

Note：Product information may be optimized and upgraded. Please refer to the actual label information for accuracy.

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.