Chinese Name |
α-辅肌动蛋白1 |
Target |
ACTN1 |
Synonym |
ACTN 1,ACTN1_HUMAN,Alpha Actinin 1,Alpha actinin cytoskeletal isoform,Alpha-actinin cytoskeletal isoform,Alpha-actinin-1,FLJ40884,FLJ54432,Actinin Alpha 1,F-Actin Cross-Linking Protein,Non-Muscle Alpha-Actinin-1,Actinin,Alpha 1,Actinin 1 Smooth Muscle,BDPLT15 |
Backgroud |
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. |
Swiss Prot |
P12814 |
Gene ID |
87 |
Subcellular Localization |
Cell junction Cell membrane Cell projection Cytoplasm Z line cytoskeleton myofibril ruffle sarcomere |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
103kDa |
Dilution Ratio |
WB 1:500-2000. IHC 1:50-200. |
Immunogen |
Recombinant protein of human ACTN1 |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃. Avoid freeze / thaw cycles. |
Appearance |
Liquid |
Unit |
Piece |
Cross-Reactivity |
Human;Mouse;Monkey |
Application |
WB;IHC |
Specification |
50ul 100ul |