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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > PKI-402CAS：1173204-81-3
Molecular Formula：C29H34N10O3
Molecular Weight：570.65
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1173204-81-3 |
| Name | PKI-402 |
| Molecular Formula | C29H34N10O3 |
| Molecular Weight | 570.65 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18251484 |
| SMILES | CCN1C2=C(C(=NC(=N2)C3=CC=C(C=C3)NC(=O)NC4=CC=C(C=C4)C(=O)N5CCN(CC5)C)N6CCOCC6)N=N1 |
| InChIKey | ZAXFYGBKZSQBIV-UHFFFAOYSA-N |
| InChI | InChI=1S/C29H34N10O3/c1-3-39-27-24(34-35-39)26(37-16-18-42-19-17-37)32-25(33-27)20-4-8-22(9-5-20)30-29(41)31-23-10-6-21(7-11-23)28(40)38-14-12-36(2)13-15-38/h4-11H，3，12-19H2，1-2H3，(H2，30，31，41) |
| PubChem CID | 44187953 |
| Target Point | PI3K;mTOR |
| Passage | PI3K/Akt/mTOR |
| Background | PKI-402 is a potent inhibitor of PI3K and mTOR. |
| Biological Activity | PKI-402 is a selective， reversible， ATP-competitive inhibitor of PI3K， including PI3K-α mutants， and mTOR (IC50=2， 3， 7，14 and 16 nM for PI3Kα， mTOR， PI3Kβ， PI3Kδ and PI3Kγ).[1] |
| Data Literature Source | [1]. Mallon R et al. Antitumor efficacy profile of PKI-402， a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor. Mol Cancer Ther. 2010 Apr;9(4):976-84. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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