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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > AT-13148CAS：1056901-62-2
Molecular Formula：C17H16ClN3O
Molecular Weight：313.78
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1056901-62-2 |
| Name | AT-13148 |
| Molecular Formula | C17H16ClN3O |
| Molecular Weight | 313.78 |
| Solubility | Soluble in DMSO ≥3mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25976789 |
| SMILES | C1=CC(=CC=C1C2=CNN=C2)C(CN)(C3=CC=C(C=C3)Cl)O |
| InChIKey | IIRWNGPLJQXWFJ-KRWDZBQOSA-N |
| InChI | InChI=1S/C17H16ClN3O/c18-16-7-5-15(6-8-16)17(22，11-19)14-3-1-12(2-4-14)13-9-20-21-10-13/h1-10，22H，11，19H2，(H，20，21)/t17-/m0/s1 |
| PubChem CID | 24905401 |
| Target Point | Akt;PKA;ROCK;Ribosomal S6 Kinase (RSK) |
| Passage | PI3K/Akt/mTOR;Stem Cells; Protein Tyrosine Kinase/RTK;MAPK |
| Background | It is an orally active, ATP-competitive inhibitor of AGC kinase that inhibits the activity of Akt1/Akt2/Akt3, p70S6K, PKA and ROCKI/ROCKII. |
| Biological Activity | AT13148 is an orally active and ATP-competitive， multi-AGC kinase inhibitor with IC50s of 38 nM/402 nM/50 nM， 8 nM， 3 nM， and 6 nM/4 nM for Akt1/2/3， p70S6K， PKA， and ROCKI/II， respectively.[1-2] |
| Data Literature Source | [1]. Yap TA， et al. AT13148 is a novel， oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. Clin Cancer Res. 2012 Jul 15;18(14):3912-23. [2]. Xi Y， et al. AT13148， a first-in-class multi-AGC kinase inhibitor， potently inhibits gastric cancer cells both in vitro and in vivo. Biochem Biophys Res Commun. 2016 Sep 9;478(1):330-6 |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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