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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > WYE-687CAS：1062161-90-3
Molecular Formula：C28H32N8O3
Molecular Weight：528.61
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
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| CAS | 1062161-90-3 |
| Name | WYE-687 |
| Molecular Formula | C28H32N8O3 |
| Molecular Weight | 528.61 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)CC5=CN=CC=C5)C(=N2)N6CCOCC6 |
| InChIKey | VDOCQQKGPJENHJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C28H32N8O3/c1-38-28(37)31-22-6-4-21(5-7-22)25-32-26(35-13-15-39-16-14-35)24-18-30-36(27(24)33-25)23-8-11-34(12-9-23)19-20-3-2-10-29-17-20/h2-7，10，17-18，23H，8-9，11-16，19H2，1H3，(H，31，37) |
| PubChem CID | 25229450 |
| Target Point | mTOR;PI3K |
| Passage | PI3K/Akt/mTOR |
| Background | WYE-687 is an ATP-competitive mTOR inhibitor that inhibits mTORC1 and mTORC2 activation. WYE-687 also inhibits PI3Kα and PI3Kγ. |
| Biological Activity | WYE-687 is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM. WYE-687 concurrently inhibits activation of mTORC1 and mTORC2. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM， respectively.[1-2] |
| Data Literature Source | [1]. Yu K， et al. Biochemical， cellular， and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40. [2]. Cheng F， et al. Preclinical evaluation of WYE-687， a mTOR kinase inhibitor， as a potential anti-acute myeloid leukemia agent. Biochem Biophys Res Commun. 2016 Feb 5;470(2):324-330. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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