{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > XL388CAS：1251156-08-7
Molecular Formula：C23H22FN3O4S
Molecular Weight：455.5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
Qty：
Size：
| CAS | 1251156-08-7 |
| Name | XL388 |
| Molecular Formula | C23H22FN3O4S |
| Molecular Weight | 455.5 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CC1=C(C=CC(=C1F)S(=O)(=O)C)C(=O)N2CCOC3=C(C2)C=C(C=C3)C4=CN=C(C=C4)N |
| InChIKey | LNFBAYSBVQBKFR-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2，29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8，11-12H，9-10，13H2，1-2H3，(H2，25，26) |
| PubChem CID | 59604787 |
| Target Point | mTOR |
| Passage | PI3K/Akt/mTOR |
| Background | XL388 is a potent ATP-competitive mTOR inhibitor that inhibits both mTORC1 and mTORC2. |
| Biological Activity | XL388 is a highly potent and ATP-competitive mTOR inhibitor with an IC50 of 9.9 nM. XL388 simultaneously inhibits both mTORC1 and mTORC2.[1-2] |
| Data Literature Source | [1]. Takeuchi CS， et al. Discovery of a novel class of highly potent， selective， ATP-competitive， and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR). J Med Chem. 2013 Mar 28;56(6):2218-34. [2]. Zhu YR， et al. The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models. Oncotarget. 2016 Aug 2;7(31):49527-49538. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
