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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > S-49076CAS：1265965-22-7
Molecular Formula：C22H22N4O4S
Molecular Weight：438.5
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1265965-22-7 |
| Name | S-49076 |
| Molecular Formula | C22H22N4O4S |
| Molecular Weight | 438.5 |
| Solubility | Soluble in DMSO ≥3mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1COCCN1CC2=CNC(=C2)C=C3C4=C(C=CC(=C4)CN5C(=O)CSC5=O)NC3=O |
| InChIKey | AREYWCZYVPSHGS-NVMNQCDNSA-N |
| InChI | InChI=1S/C22H22N4O4S/c27-20-13-31-22(29)26(20)12-14-1-2-19-17(8-14)18(21(28)24-19)9-16-7-15(10-23-16)11-25-3-5-30-6-4-25/h1-2，7-10，23H，3-6，11-13H2，(H，24，28)/b18-9- |
| PubChem CID | 49870909 |
| Target Point | FGFR;c-Met/HGFR;AXL/MER |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | It is a potent Met (c-Met), AXL/MER and FGFR1/2/3 inhibitor. |
| Biological Activity | S49076 is a novel， potent inhibitor of MET， AXL/MER， and FGFR1/2/3 with IC50 values below 20 nM.[1] |
| Data Literature Source | [1]. Burbridge MF， et al. S49076 is a novel kinase inhibitor of MET， AXL， and FGFR with strong preclinical activity alone and in association with bevacizumab. Mol Cancer Ther. 2013 Sep;12(9):1749-62. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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