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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Vatalanib free baseCAS：212141-54-3
Molecular Formula：C20H15ClN4
Molecular Weight：346.81
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 212141-54-3 |
| Name | Vatalanib free base |
| Molecular Formula | C20H15ClN4 |
| Molecular Weight | 346.81 |
| Solubility | Soluble in DMSO ≥6mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD08458963 |
| SMILES | C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4 |
| InChIKey | YCOYDOIWSSHVCK-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H，13H2，(H，23，25) |
| PubChem CID | 151194 |
| Target Point | VEGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | It is an inhibitor of VEGFR2/KDR. |
| Biological Activity | Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM.[1-3] |
| Data Literature Source | [1]. Wood JM， et al. PTK787/ZK 222584， a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases， impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000， 60(8 [2]. Murakami M， et al. Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann Surg Oncol. 2011， 18(2)， 589-596. [3]. Wan J， et al. Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone. Oncol Rep. 2016 Mar;35(3):1297-308. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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