Rigosertib
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Cat.No：IR2440 Solarbio
CAS：592542-59-1
Molecular Formula：C21H25NO8S
Molecular Weight：451.49
Storage：Powder:-20℃，2 years
Purity：≥98%
Appearance：Solid
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Inhibitors & Antagonists & Agonists
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Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
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HIF
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Apoptosis
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Rigosertib
Product Information
| CAS | 592542-59-1 |
| Name | Rigosertib |
| Molecular Formula | C21H25NO8S |
| Molecular Weight | 451.49 |
| Solubility | Soluble in DMSO ≥5mg/mL(This product is not stable in solution, it is recommended that you use it now) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years |
| SMILES | COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)O |
| InChIKey | OWBFCJROIKNMGD-BQYQJAHWSA-N |
| InChI | InChI=1S/C21H25NO8S/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25，26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24/h5-11，22H，12-13H2，1-4H3，(H，23，24)/b8-7+ |
| PubChem CID | 6918736 |
| Target Point | Polo-like Kinase (PLK) |
| Passage | Cell Cycle |
| Background | Rigosertib is a multi-kinase inhibitor and selective anticancer compound that induces cell apoptosis by inhibiting PI3K/Akt pathway, promoting phosphorylation of histone H2AX and inducing G2/M phase arrest in the cell cycle. Rigosertib is a selective non-ATP-competitive PLK1 inhibitor. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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