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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Regorafenib HydrochlorideCAS：835621-07-3
Molecular Formula：C21H16Cl2F4N4O3
Molecular Weight：519.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 835621-07-3 |
| Name | Regorafenib Hydrochloride |
| Molecular Formula | C21H16Cl2F4N4O3 |
| Molecular Weight | 519.28 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.Cl |
| InChIKey | ACSWJKPZXNIVMY-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H15ClF4N4O3.ClH/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24，25)26;/h2-10H，1H3，(H，27，31)(H2，29，30，32);1H |
| PubChem CID | 66577009 |
| Target Point | VEGFR;PDGFR;RET;c-Kit;Raf |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK;MAPK |
| Background | It is a multi-target inhibitor targeting VEGFR1/2, PDGFRβ, Kit, RET and Raf-1. |
| Biological Activity | Regorafenib Hydrochloride (BAY 73-4506 hydrochloride) is a multi-target inhibitor for VEGFR1/2/3， PDGFRβ， Kit， RET and Raf-1 with IC50s of 13/4.2/46， 22， 7， 1.5 and 2.5 nM， respectively.[1-3] |
| Data Literature Source | [1]. Wilhelm SM， et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic， stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer， 2011， 129(1)， 245-255. [2]. Heng DY， et al. Targeted therapy for metastatic renal cell carcinoma: current treatment and future directions. Ther Adv Med Oncol， 2010， 2(1)， 39-49. [3]. Carr BI， et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition， quiescence， and recovery. J Cell Physiol， 2013， 228(2)， 292-297. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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