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My CartReactivity：Human
Application：WB,IHC
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze/thaw cycles.
Gene ID：91801
Host：Rabbit
Qty：
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| Name | Anti-ALKBH8 Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Predicted Reactivity | Monkey;Cow |
| Dilution Ratio | WB 1:1000-3000.IHC 1:50-200. |
| Target | ALKBH8 |
| Background | Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg and tRNA(Glu，and does not bind tRNA(Lys(PubMed:20308323. Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain，giving rise to 5-(S-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly. Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis. |
| Swiss Prot | Q96BT7 |
| Gene ID | 91801 |
| Subcellular Location | Cytoplasm Nucleus |
| Immunogen | A synthetic peptide of human ALKBH8 |
| Public Immunogen Range | 330-380/664aa |
| Calculated MW | 26/27/75/76kDa |
| Observed MW | 75kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage | Store at -20℃. Avoid freeze/thaw cycles. |
| Unit | Piece |
| Specification | 20ul 50ul 100ul |
| Reactivity | Human |
| Application | WB IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Western blot analysis with ALKBH8 antibody diluted at 1:2000;Lane: HeLa.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with ALKBH8 antibody diluted at 1:100.
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