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2'-O-Methyltransferase
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2'-O-Methyltransferase is a methyltransferase encoded by cowpox virus DNA expressed by recombinant E.coli. It is a methyltransferase that further transforms Cap0 cap structure into Cap1 cap structure. It uses S-Adenosylmethionine (SAM) as the methyl donor and adds methyl groups to the 2'-O site of the first nucleotide at the 5' end of RNA adjacent to the cap structure (Cap0) to form mRNA with the Cap1 structure. It could further reduce the immunogenicity of mRNA itself and increase the expression level of encoded protein after transfection.
Remark：
These protocols are for reference only. Solarbio does not independently validate these
methods.
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