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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：9817
Application：Blocking Peptide of K108661P Antibody
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| Name | KEAP1 Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | Q14145 |
| Gene ID | 9817 |
| Background | Substrate-specific adapter of a BCR E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions， the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2， a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress， different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1， leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex， promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy， KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62， leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62， increasing SQSTM1/p62 sequestering activity and degradation. The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome. |
| Application | Blocking Peptide of K108661P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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