{{cart_num}}
My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：6117
Application：Blocking Peptide of K109846P Antibody
Qty：
Size：
| Name | RPA1 Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | P27694 |
| Gene ID | 6117 |
| Background | As part of the heterotrimeric replication protein A complex (RPA/RP-A)， binds and stabilizes single-stranded DNA intermediates， that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel， recruits and activates different proteins and complexes involved in DNA metabolism. Thereby， it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage， the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP， which is involved in replication fork restart， to sites of DNA damage. May also play a role in telomere maintenance. As part of the alternative replication protein A complex， aRPA， binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing， canonical RPA complex， may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC)， the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. |
| Application | Blocking Peptide of K109846P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no experimental images.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
