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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：6478
Application：Blocking Peptide of K110799P Antibody
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| Name | SIAH2 Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | O43255 |
| Gene ID | 6478 |
| Interval Range | 105-155/324aa |
| Background | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:9334332， PubMed:11483518， PubMed:19224863). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:9334332， PubMed:11483518， PubMed:19224863). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:9334332， PubMed:11483518， PubMed:19224863). Triggers the ubiquitin-mediated degradation of many substrates， including proteins involved in transcription regulation (GPS2， POU2AF1， PML， NCOR1)， a cell surface receptor (DCC)， an antiapoptotic protein (BAG1)， and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:9334332， PubMed:11483518， PubMed:19224863). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (PubMed:22878263). It is thereby involved in apoptosis， tumor suppression， cell cycle， transcription and signaling processes (PubMed:9334332， PubMed:11483518， PubMed:19224863， PubMed:22878263). Has some overlapping function with SIAH1 (PubMed:9334332， PubMed:11483518， PubMed:19224863). Triggers the ubiquitin-mediated degradation of TRAF2， whereas SIAH1 does not (PubMed:12411493). Promotes monoubiquitination of SNCA (PubMed:19224863). Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (PubMed:26392558). Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR)， leading to their degradation and subsequent stabilization of ATF4 (By similarity). |
| Application | Blocking Peptide of K110799P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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