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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：4361
Application：Blocking Peptide of K110835P Antibody
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| Name | MRE11 Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | P49959 |
| Gene ID | 4361 |
| Interval Range | 650-700/708aa |
| Background | Component of the MRN complex， which plays a central role in double-strand break (DSB) repair， DNA recombination， maintenance of telomere integrity and meiosis (PubMed:9651580， PubMed:9590181， PubMed:9705271， PubMed:11741547， PubMed:29670289). The complex possesses single-strand endonuclease activity and double-strand-specific 3’-5’ exonuclease activity， which are provided by MRE11 (PubMed:9651580， PubMed:9590181， PubMed:9705271， PubMed:11741547， PubMed:29670289). RAD50 may be required to bind DNA ends and hold them in close proximity (PubMed:9651580， PubMed:9590181， PubMed:9705271， PubMed:11741547， PubMed:29670289). This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates， and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580， PubMed:9590181， PubMed:9705271， PubMed:11741547， PubMed:29670289， PubMed:30612738). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). |
| Application | Blocking Peptide of K110835P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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