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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：55159
Application：Blocking Peptide of K111086P Antibody
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| Name | RFWD3 Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | Q6PCD5 |
| Gene ID | 55159 |
| Interval Range | 60-110/774aa |
| Background | E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1， RPA2 and RPA3 subunits) and RAD51 at stalled replication forks， leading to remove them from DNA damage sites and promote homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage， and acts as a positive regulator of p53/TP53 stability， thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation， interacts with MDM2 and enhances p53/TP53 ubiquitination， possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. |
| Application | Blocking Peptide of K111086P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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