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My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：83737
Application：Blocking Peptide of K111513P Antibody
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| Name | ITCH Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | Q96J02 |
| Gene ID | 83737 |
| Interval Range | 405-455/903aa |
| Background | Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14602072， PubMed:17028573， PubMed:16387660， PubMed:18718448， PubMed:18718449， PubMed:11046148， PubMed:19592251， PubMed:19116316， PubMed:19881509， PubMed:20491914， PubMed:20392206， PubMed:20068034， PubMed:23146885， PubMed:24790097， PubMed:25631046). Catalyzes ’Lys-29’-， ’Lys-48’- and ’Lys-63’-linked ubiquitin conjugation (PubMed:17028573， PubMed:18718448， PubMed:19131965， PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex， comprising also TNFAIP3， TAX1BP1 and RNF11， that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed， TNFAIP3 deubiquitinates ’Lys-63’ polyubiquitin chains on RIPK1 and catalyzes the formation of ’Lys-48’-polyubiquitin chains (PubMed:19131965). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (PubMed:19131965). Ubiquitinates RIPK2 by ’Lys-63’-linked conjugation and influences NOD2-dependent signal transduction pathways (PubMed:19592251). Regulates the transcriptional activity of several transcription factors， and probably plays an important role in the regulation of immune response (PubMed:18718448， PubMed:20491914). Ubiquitinates NFE2 by ’Lys-63’ linkages and is implicated in the control of the development of hematopoietic lineages (PubMed:18718448). Mediates JUN ubiquitination and degradation (By similarity). Mediates JUNB ubiquitination and degradation (PubMed:16387660). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (By similarity). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (PubMed:19881509). Ubiquitinates MAVS through ’Lys-48’-linked conjugation resulting in MAVS proteasomal degradation (PubMed:19881509). Following ligand stimulation， regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (PubMed:23146885). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072， PubMed:23146885). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation， in the absence of ligand， through ’Lys-29’-linked polyubiquitination (PubMed:17028573， PubMed:18628966， PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through ’Lys-48’-linked conjugation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (PubMed:20068034). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Inhibits the replication of influenza A virus (IAV) via ubiquitination of IAV matrix protein 1 (M1) through ’Lys-48’-linked conjugation resulting in M1 proteasomal degradation (PubMed:30328013). |
| Application | Blocking Peptide of K111513P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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