{{cart_num}}
My CartStorage：Store at -20℃，2 years.Avoid freeze/thaw cycles.
Appearance：Lyophilized powder
Gene ID：2185
Application：Blocking Peptide of K111567P Antibody
Qty：
Size：
| Name | PTK2B Antibody Blocking Peptide |
| Appearance | Lyophilized powder |
| Storage | Store at -20℃，2 years.Avoid freeze/thaw cycles. |
| Swiss Prot | Q14289 |
| Gene ID | 2185 |
| Interval Range | 750-800/1009aa |
| Background | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton， cell polarization， cell migration， adhesion， spreading and bone remodeling. Plays a role in the regulation of the humoral immune response， and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells， and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors， immune receptors， G-protein coupled receptors (GPCR)， cytokine， chemokine and growth factor receptors， and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues， creating binding sites for scaffold proteins， effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade， including activation of MAPK1/ERK2， MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases， such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus， and thereby regulates P53/TP53 activity， P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold， binding to both PDPK1 and SRC， thereby allowing SRC to phosphorylate PDPK1 at ’Tyr-9， ’Tyr-373’， and ’Tyr-376’. Promotes phosphorylation of NMDA receptors by SRC family members， and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca2+ levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1， NPHP1， KCNA2 and SHC1. Promotes phosphorylation of ASAP2， RHOU and PXN; this requires both SRC and PTK2/PYK2. |
| Application | Blocking Peptide of K111567P Antibody |
| Source | Synthetic |
| Purification Method | HPLC |
| Biological Activity | Not tested |
| Unit | Piece |
| Specification | 500ug |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no experimental images.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
